Discussion of some ‘knowns’ and some ‘unknowns’ about the tumour suppressor p53
Author:
Affiliation:
1. The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
2. Department of Medical Biology, University of Melbourne, Melbourne, Australia
Funder
National Health and Medical Research Council
Leukemia & Lymphoma Society
Cancer Council of Victoria
Leukaemia Foundation
Victorian Cancer Agency
Publisher
Oxford University Press (OUP)
Subject
Cell Biology,Genetics,Molecular Biology,General Medicine
Link
http://academic.oup.com/jmcb/article-pdf/11/3/212/28504323/mjy077.pdf
Reference133 articles.
1. p53 loss-of-heterozygosity is a necessary prerequisite for mutant p53 stabilization and gain-of-function in vivo;Alexandrova;Cell Death Dis.,2017
2. Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment;Alexandrova;Nature,2015
3. Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms;Allen;eLife,2014
4. Characterization of novel markers of senescence and their prognostic potential in cancer;Althubiti;Cell Death Dis.,2014
5. Mutant TRP53 exerts a target gene selective dominant negative effect to drive tumor development;Aubrey;Genes Dev.,2018
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