CD4 Count at Entry into Care and at Antiretroviral Therapy Prescription among Adults with Human Immunodeficiency Virus in the United States, 2005-2018

Author:

Lee Jennifer S1ORCID,Humes Elizabeth A1,Hogan Brenna C1,Buchacz Kate2,Eron Joseph J3,Gill M John4,Sterling Timothy R5,Rebeiro Peter F56,Lima Viviane Dias7,Mayor Angel8,Silverberg Michael J9,Horberg Michael A10,Moore Richard D11,Althoff Keri N1,Benson Constance A,Bosch Ronald J,Kirk Emory-Grady Gregory D,Mayer Kenneth H,Grasso Chris,Hogg Robert S,Richard Harrigan P,Montaner Julio S G,Yip Benita,Zhu Julia,Salters Kate,Gabler Karyn,Buchacz Kate,Li Jun,Gebo Kelly A,Moore Johns Richard D,Moore Richard D,Carey John T,Rodriguez Benigno,Horberg Michael A,Silverberg Michael J,Thorne Jennifer E,Brown Todd,Tien Phyllis,D’Souza Gypsyamber,Crouzat Frederic,Loutfy Mona,Smith Graham,Gupta Meenakshi,Klein Marina B,Rabkin Charles,Kroch Abigail,Burchell Ann,Betts Adrian,Lindsay Joanne,Nijhawan Ank,Hunter-Mellado Robert F,Mayor Angel M,John Gill M,Martin Jeffrey N,Li Jun,Brooks John T,Saag Michael S,Mugavero Michael J,Willig James,Bamford Laura,Karris Maile,Eron Joseph J,Napravnik Sonia,Kitahata Mari M,Crane Heidi M,Sterling Timothy R,Haas David,Rebeiro Peter,Turner Megan,Park Lesley,Justice Amy,Moore Richard D,Althoff Keri N,Gange Stephen J,Kitahata Mari M,Lee Jennifer S,Saag Michael S,Horberg Michael A,Klein Marina B,McKaig Rosemary G,Freeman Aimee M,Moore Richard D,Althoff Keri N,Freeman Aimee M,Kitahata Mari M,Van Rompaey Stephen E,Crane Heidi M,Morton Liz,McReynolds Justin,Lober William B,Gange Stephen J,Lee Jennifer S,Hogan Brenna,You Bin,Humes Elizabeth,Gerace Lucas,Stewart Cameron,Coburn Sally,

Affiliation:

1. Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA

2. Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

3. Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

4. Southern Alberta HIV Clinic, Calgary, Alberta, Canada

5. Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA

6. Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA

7. BC Centre for Excellence in HIV/AIDS, University of British Columbia, Vancouver, British Columbia, Canada

8. Department of Medicine, Universidad Central del Caribe, Bayamon, Puerto Rico

9. Kaiser Permanente Northern California, Oakland, California, USA

10. Mid-Atlantic Permanente Research Institute, Kaiser Permanente Mid-Atlantic States, Rockville, Maryland, USA

11. Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA

Abstract

Abstract From 2005 to 2018, among 32013 adults with human immunodeficiency virus entering care, median time to antiretroviral therapy (ART) prescription declined from 69 to 6 days, CD4 count at entry into care increased from 300 to 362 cells/μL, and CD4 count at ART prescription increased from 160 to 364 cells/μL.

Funder

NIH

CDC

Agency for Healthcare Research and Quality

Health Resources and Services Administration

Canadian Institutes of Health Research

Ontario Ministry of Health and Long Term Care

Government of Alberta

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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