Chloroquine Inhibits the Release of Inflammatory Cytokines by Human Lung Explants-Reference-Cited by-同舟云学术

Chloroquine Inhibits the Release of Inflammatory Cytokines by Human Lung Explants

Published:2020-05-08 Issue:16 Volume:71 Page:2265-2268
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Grassin-Delyle Stanislas¹²,Salvator Hélène¹³,Brollo Marion³,Catherinot Emilie¹,Sage Edouard¹⁴,Couderc Louis-Jean¹³,Naline Emmanuel¹³,Devillier Philippe¹³^ORCID

Affiliation:

1. Department of Respiratory Diseases, Foch Hospital, Suresnes, France

2. INSERM Infection and Inflammation, Département de Biotechnologie de la Santé, University Paris-Saclay, Montigny-le-Bretonneux, France

3. Laboratory of Research in Respiratory Pharmacology, Exhalomics Facility, Foch Hospital, University Paris-Saclay, Suresnes, France

4. UMR0892, INR AE, University Paris-Saclay, Jouy-en-Josas, France

Abstract

Abstract On human lung parenchymal explants, chloroquine concentration clinically achievable in the lung (100 µM) inhibited the lipopolysaccharide-induced release of TNF-ɑ (by 76%), IL-6 (by 68%), CCL2 (by 72%), and CCL3 (by 67%). Besides its antiviral activity, chloroquine might also mitigate the cytokine storm associated with severe pneumonia caused by coronaviruses.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciaa546/33563468/ciaa546.pdf

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