Chromosome structure modeling tools and their evaluation in bacteria

Author:

Liu Tong12,Qiu Qin-Tian12,Hua Kang-Jian12,Ma Bin-Guang12ORCID

Affiliation:

1. Hubei Key Laboratory of Agricultural Bioinformatics , , Wuhan 430070 , China

2. College of Informatics, Huazhong Agricultural University , , Wuhan 430070 , China

Abstract

Abstract The three-dimensional (3D) structure of bacterial chromosomes is crucial for understanding chromosome function. With the growing availability of high-throughput chromosome conformation capture (3C/Hi-C) data, the 3D structure reconstruction algorithms have become powerful tools to study bacterial chromosome structure and function. It is highly desired to have a recommendation on the chromosome structure reconstruction tools to facilitate the prokaryotic 3D genomics. In this work, we review existing chromosome 3D structure reconstruction algorithms and classify them based on their underlying computational models into two categories: constraint-based modeling and thermodynamics-based modeling. We briefly compare these algorithms utilizing 3C/Hi-C datasets and fluorescence microscopy data obtained from Escherichia coli and Caulobacter crescentus, as well as simulated datasets. We discuss current challenges in the 3D reconstruction algorithms for bacterial chromosomes, primarily focusing on software usability. Finally, we briefly prospect future research directions for bacterial chromosome structure reconstruction algorithms.

Funder

National Natural Science Foundation of China

Publisher

Oxford University Press (OUP)

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