Relationship of Telomere Length to Fat Redistribution in HIV-Reference-Cited by-同舟云学术

Relationship of Telomere Length to Fat Redistribution in HIV

Published:2020-10-27 Issue:12 Volume:7 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Iyengar Sanjna¹,Cȏté Hélène C F²,Fitch Kathleen V¹^ORCID,Torriani Martin¹³,Feldpausch Meghan¹,Srinivasa Suman¹^ORCID

Affiliation:

1. Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA

2. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada

3. Division of Musculoskeletal Imaging and Intervention, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA

Abstract

Abstract Persons with HIV demonstrate increased risk for aging-associated complications and have reduced telomere length (TL) compared with age-matched persons without HIV. Our data show that greater visceral fat is related to reduced TL in HIV, independent of age and smoking. Fat redistribution may be a relevant mediator of TL attrition in HIV.

Funder

National Institutes of Health

National Center for Research Resources

National Center for Advancing Translational Sciences

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

http://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofaa523/34037640/ofaa523.pdf

Reference21 articles.

1. Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease;Triant;J Clin Endocrinol Metab,2007