The emergence and impact of the M1UK lineage on invasive Group A Streptococcus disease in Aotearoa New Zealand-Reference-Cited by-同舟云学术

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The emergence and impact of the M1UK lineage on invasive Group A Streptococcus disease in Aotearoa New Zealand

Published:2024-08-09 Issue: Volume: Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Vesty Anna¹²,Ren Xiaoyun¹,Sharma Prachi²,Lorenz Natalie²,Proft Thomas²^ORCID,Hardaker Allan¹,Straub Christina¹,Morgan Julie¹,Tiong Audrey¹,Anderson Anneka³,Webb Rachel H⁴,Bennett Julie²⁵,Carter Philip E¹,Moreland Nicole J²^ORCID

Affiliation:

1. The Institute of Environment Science and Research , Porirua , New Zealand

2. School of Medical Sciences, Faculty of Medical and Health Sciences, The University of Auckland , New Zealand

3. Te Kupenga Hauora Māori, The University of Auckland , New Zealand

4. Department of Paediatrics, Child and Youth Health, The University of Auckland , New Zealand

5. Department of Public Health, University of Otago , Wellington , New Zealand

Abstract

Abstract M1UK is associated with current surges in invasive infection globally, partly due to increased production of superantigen SpeA. We show M1UK is now the dominant invasive emm1 lineage in New Zealand and is genomically related to community infections, suggesting measures that effectively prevent GAS-pharyngitis in children could reduce invasive disease.

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofae457/58777936/ofae457.pdf

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