HLA-A*23 Is Associated With Lower Odds of Acute Retroviral Syndrome in Human Immunodeficiency Virus Type 1 Infection: A Multicenter Sub-Saharan African Study-Reference-Cited by-同舟云学术

HLA-A*23 Is Associated With Lower Odds of Acute Retroviral Syndrome in Human Immunodeficiency Virus Type 1 Infection: A Multicenter Sub-Saharan African Study

Published:2024-03-13 Issue:4 Volume:11 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Lindquist Lovisa¹²,Kilembe William³^ORCID,Karita Etienne³,Price Matt A⁴⁵,Kamali Anatoli⁶,Kaleebu Pontiano⁷⁸,Tang Jianming⁹,Allen Susan³¹⁰,Hunter Eric³¹⁰,Gilmour Jill⁴¹¹,Rowland-Jones Sarah L¹²,Sanders Eduard J¹²¹³,Hassan Amin S¹²¹⁴,Esbjörnsson Joakim¹²¹²^ORCID

Affiliation:

1. Lund University Centre, Lund University , Lund , Sweden

2. Department of Translational Medicine, Lund University , Lund , Sweden

3. Rwanda/Zambia HIV Research Group , Kigali, Rwanda and Lusaka , Zambia

4. International AIDS Vaccine Initiative , New York, New York , USA

5. Department of Epidemiology and Biostatistics, University of California, San Francisco , San Francisco, California , USA

6. International AIDS Vaccine Initiative , Nairobi , Kenya

7. Medical Research Council/Uganda Virus Centre Research Institute , Entebbe , Uganda

8. London School of Hygiene and Tropical Medicine , London , United Kingdom

9. Department of Medicine, University of Alabama at Birmingham , Birmingham, Alabama , USA

10. Emory Vaccine Center, Emory University , Atlanta, Georgia , USA

11. Human Immunology Laboratory , International AIDS Vaccine Initiative, London , United Kingdom

12. Nuffield Department of Clinical Medicine, University of Oxford , Oxford , United Kingdom

13. Aurum Institute , Johannesburg , South Africa

14. Kenya Medical Research Institute/Wellcome Trust Research Programme , Kilifi , Kenya

Abstract

Abstract The role of human leukocyte antigen (HLA) class I and killer immunoglobulin-like receptor molecules in mediating acute retroviral syndrome (ARS) during human immunodeficiency virus type 1 (HIV-1) infection is unclear. Among 72 sub-Saharan African adults, HLA-A*23 was associated with lower odds of ARS (adjusted odds ratio, 0.10 [95% confidence interval, .01–.48]; P = .009), which warrants further studies to explore its role on HIV-1–specific immunopathogenesis.

Funder

United States Agency for International Development

Swedish Research Council

Swedish Society for Medical Research

Wellcome Trust

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofae129/56962851/ofae129.pdf

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