Pretreatment and Acquired Drug Resistance in Children With Human Immunodeficiency Virus Type 1 in Jos, Nigeria-Reference-Cited by-同舟云学术

Pretreatment and Acquired Drug Resistance in Children With Human Immunodeficiency Virus Type 1 in Jos, Nigeria

Published:2024-02-19 Issue:3 Volume:11 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Ebonyi Augustine O¹,Okpokwu Jonathan²,Rawizza Holly³^ORCID,Chebu Philippe⁴,Chaplin Beth³,Hamel Donald³,Oguche Stephen¹,Agbaji Oche O⁵,Sagay Atiene S⁶,Kanki Phyllis J³,Imade Godwin E²⁶^ORCID

Affiliation:

1. Department of Paediatrics, University of Jos, Jos University Teaching Hospital , Jos , Nigeria

2. AIDS Prevention Initiative in Nigeria–supported ISO 15189 Laboratory, Jos University Teaching Hospital , Jos , Nigeria

3. Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health , Boston, Massachusetts , USA

4. APIN Public Health Initiatives, Plot 1551, Apo Resettlement, Apo District , Abuja, FCT , Nigeria

5. Department of Medicine, University of Jos, Jos University Teaching Hospital , Jos , Nigeria

6. Department of Obstetrics and Gynaecology, University of Jos, Jos University Teaching Hospital , Jos , Nigeria

Abstract

Abstract We determined pretreatment and acquired human immunodeficiency virus (HIV) drug resistance among children with HIV type 1 (HIV-1) in Jos, Nigeria. The majority (71%) of those who failed first-line antiretroviral therapy were on a nevirapine-containing regimen. The prevalence of pretreatment (48%) and acquired (76%) HIV drug resistance mutations was high in our study. Wider access to HIV drug resistance testing after treatment failure is necessary to optimize second-line treatment options among children with HIV in Nigeria.

Funder

STAMINA

Fogarty International Center

Office of the Director

National Institute of Neurological Disorders and Stroke

National Institute of Nursing Research

National Institutes of Health

US Department of Health and Human Services

Health Resources and Services Administration

Centers for Disease Control and Prevention

Publisher

Oxford University Press (OUP)