Therapeutic Myths in Solid Organ Transplantation Infectious Diseases

Author:

Goodlet Kellie J1ORCID,McCreary Erin K2,Nailor Michael D3,Barnes Darina4,Brokhof Marissa M5,Bova Sarah6,Clemens Evan7,Kelly Beth8,Lichvar Alicia9,Pluckrose Dawn M10,Summers Bryant B11,Szempruch Kristen R12,Tchen Stephanie13

Affiliation:

1. Department of Pharmacy Practice, Midwestern University , Glendale, Arizona , USA

2. Department of Medicine, Division of Infectious Diseases, University of Pittsburgh Medical Center , Pittsburgh, Pennsylvania , USA

3. Department of Pharmacy Services, St Joseph's Hospital and Medical Center , Phoenix, Arizona , USA

4. Department of Pharmacy, Comprehensive Transplant Center, Cedars Sinai Medical Center , Los Angeles, California , USA

5. Department of Pharmacy, Rush University Medical Center , Chicago, Illinois , USA

6. Department of Pharmacy, University of Maryland Medical Center , Baltimore, Maryland , USA

7. Department of Pharmacy, University of Washington Medical Center , Seattle, Washington , USA

8. Department of Pharmacy, Indiana University Health , Indianapolis, Indiana , USA

9. Center for Transplantation, UC San Diego Health , San Diego, California , USA

10. Department of Pharmacy, Tufts Medical Center , Boston, Massachusetts , USA

11. Comprehensive Transplant Center, The Ohio State University Wexner Medical Center , Columbus, Ohio , USA

12. Department of Pharmacy, University of North Carolina Medical Center , Chapel Hill, North Carolina , USA

13. Department of Pharmacy, Froedtert Hospital , Milwaukee, Wisconsin , USA

Abstract

Abstract Infection management in solid organ transplantation poses unique challenges, with a diverse array of potential pathogens and associated antimicrobial therapies. With limited high-quality randomized clinical trials to direct optimal care, therapeutic “myths” may propagate and contribute to suboptimal or excessive antimicrobial use. We discuss 6 therapeutic myths with particular relevance to solid organ transplantation and provide recommendations for infectious diseases clinicians involved in the care of this high-risk population.

Publisher

Oxford University Press (OUP)

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