Clinical Correlation of Adenoviral Load in the Respiratory Tract Measured by Digital PCR in Immunocompromised Children-Reference-Cited by-同舟云学术

Clinical Correlation of Adenoviral Load in the Respiratory Tract Measured by Digital PCR in Immunocompromised Children

Published:2023-01-23 Issue:2 Volume:10 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Hijano Diego R¹^ORCID,Ferrolino Jose A¹,Hidinger Jennifer¹,Brazelton Jessica N²,Gu Zhengming²,Suganda Sri²,Glasgow Heather L²,Allison Kim J¹,Peterson Megan¹,Dallas Ronald H¹,Maron Gabriela¹,Hayden Randall T²

Affiliation:

1. Department of Infectious Diseases, St. Jude Children Research Hospital , Memphis, Tennessee , USA

2. Department of Pathology, St. Jude Children Research Hospital , Memphis, Tennessee , USA

Abstract

Abstract Immunocompromised patients can have life-threatening adenoviral infection. Viral load in blood and stool is commonly used to guide antiviral therapy. We developed and evaluated a digital polymerase chain reaction assay to quantify human adenovirus in the respiratory tract and showed that higher peak load correlates with disseminated infection, mechanical ventilation, and death.

Funder

American Lebanese Syrian Associated Charities

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofad030/48827671/ofad030.pdf

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