Structure, function and therapeutic implications of OB-fold proteins: A lesson from past to present

Author:

Amir Mohd,Mohammad Taj,Dohare Ravins,Islam Asimul,Ahmad Faizan,Imtaiyaz Hassan Md

Abstract

AbstractOligonucleotide/oligosaccharide-binding (OB)-fold proteins play essential roles in the regulation of genome and its correct transformation to the subsequent generation. To maintain the genomic stability, OB-fold proteins are implicated in various cellular processes including DNA replication, DNA repair, cell cycle regulation and maintenance of telomere. The diverse functional spectrums of OB-fold proteins are mainly due to their involvement in protein–DNA and protein–protein complexes. Mutations and consequential structural alteration in the OB-fold proteins often lead to severe diseases. Here, we have investigated the structure, function and mode of action of OB-fold proteins (RPA, BRCA2, DNA ligases and SSBs1/2) in cellular pathways and their relationship with diseases and their possible use in therapeutic intervention. Due to the crucial role of OB-fold proteins in regulating the key physiological process, a detailed structural understanding in the context of underlying mechanism of action and cellular complexity offers a new avenue to target OB-proteins for therapeutic intervention.

Funder

Indian National Academy of Science

Department of Science and Technology and the Indian Council of Medical Research

Council of Scientific and Industrial Research

Publisher

Oxford University Press (OUP)

Subject

Genetics,Molecular Biology,Biochemistry,General Medicine

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