Markers of CNS Injury in Adults Living With HIV With CSF HIV Not Detected vs Detected <20 Copies/mL-Reference-Cited by-同舟云学术

Markers of CNS Injury in Adults Living With HIV With CSF HIV Not Detected vs Detected <20 Copies/mL

Published:2019-12-01 Issue:12 Volume:6 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Farhadian Shelli F¹,Mistry Hetal²,Kirchwey Tobias²,Chiarella Jennifer²,Calvi Rachela²,Chintanaphol Michelle²,Patel Payal²,Landry Marie L³,Robertson Kevin⁴,Spudich Serena S²

Affiliation:

1. Section of Infectious Diseases, Department of Medicine, Yale School of Medicine, New Haven, Connecticut, USA

2. Department of Neurology, Yale School of Medicine, New Haven, Connecticut, USA

3. Departments of Laboratory Medicine and Medicine, Yale School of Medicine, New Haven, Connecticut, USA

4. Department of Neurology, University of North Carolina, Chapel Hill, North Carolina, USA

Abstract

Abstract The presence of quantifiable HIV RNA in cerebrospinal fluid (CSF) during antiretroviral therapy (ART) can associate with central nervous system (CNS) pathology, but the significance of RNA detected below the limit of quantification (LOQ) on a standard assay during ART remains unknown. We compared CNS parameters between individuals with CSF RNA detected below the LOQ (20 copies/mL) with those with HIV RNA not detected. Detection of CSF HIV RNA associated with decreased blood–brain barrier integrity and with decreased executive function, but not with CNS immune activation or poorer performance in overall neuropsychological testing.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

http://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofz528/31518232/ofz528.pdf

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