Affiliation:
1. College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China
2. College of Bioinformatics, Hainan Medical University, Haikou 570100, China
Abstract
AbstractLong non-coding RNAs (lncRNAs) are associated with human diseases. Although lncRNA–disease associations have received significant attention, no online repository is available to collect lncRNA-mediated regulatory mechanisms, key downstream targets, and important biological functions driven by disease-related lncRNAs in human diseases. We thus developed LncTarD (http://biocc.hrbmu.edu.cn/LncTarD/ or http://bio-bigdata.hrbmu.edu.cn/LncTarD), a manually-curated database that provides a comprehensive resource of key lncRNA–target regulations, lncRNA-influenced functions, and lncRNA-mediated regulatory mechanisms in human diseases. LncTarD offers (i) 2822 key lncRNA–target regulations involving 475 lncRNAs and 1039 targets associated with 177 human diseases; (ii) 1613 experimentally-supported functional regulations and 1209 expression associations in human diseases; (iii) important biological functions driven by disease-related lncRNAs in human diseases; (iv) lncRNA–target regulations responsible for drug resistance or sensitivity in human diseases and (v) lncRNA microarray, lncRNA sequence data and transcriptome data of an 11 373 pan-cancer patient cohort from TCGA to help characterize the functional dynamics of these lncRNA–target regulations. LncTarD also provides a user-friendly interface to conveniently browse, search, and download data. LncTarD will be a useful resource platform for the further understanding of functions and molecular mechanisms of lncRNA deregulation in human disease, which will help to identify novel and sensitive biomarkers and therapeutic targets.
Funder
National Natural Science Foundation of China
China Postdoctoral Science Foundation
China Postdoctoral Science Special Foundation
Hei Long Jiang Postdoctoral Foundation
Natural Science Foundation of Heilongjiang Province
Fundamental Research Funds for the Provincial Universities
Heilongjiang Provincial Health and Family Planning Commission of Science Foundation
Heilongjiang Provincial planning office key subjects
Publisher
Oxford University Press (OUP)
Cited by
82 articles.
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