This book aims to encourage more co-produced research addressing questions about human health, past and present, by scholars working in evolutionary medicine (EM) and palaeopathology. It highlights future research that may promote that collaboration between palaeopathology and EM. This chapter starts with the premise that EM and palaeopathology have clear synergies in that they take a deep time perspective as they explore health in both the past and the present. It introduces the volume and first provides a background to EM from its first appearance in the early 1990s, including discussions about ultimate and proximate explanations for disease. It then highlights that the field of palaeopathology was initially established much earlier than EM and it is argued that practitioners before the 1990s, often physicians, were simply not exposed to evolutionary theory in relation to the diseases they were seeing both in the living and in the dead. However, the stage now looks set for more productive collaborations. A thematic overview of the volume and its individual chapters follows within the framework of the suggested categories for study within EM. The chapter finishes with some discussion about the One Health Initiative—considered an essential area of study now and into the future—and how it relates to EM and palaeopathology.