This edition of the Grand Challenges for Social Work and Society builds on the successful first edition (2017) by updating original reviews of the field, presenting new accomplishments, and offering a blueprint for the next 5 years of the grand challenges. January 2021 marked the midpoint for what has been identified as a 10-year effort. Each of the, now 13, grand challenges shares a fresh review of the state and progress of the related field, including enhanced examination of the intersection with considerations of race and gender equity, and a discussion on future direction for the work. The progress documented in this volume in advancing measurable outcomes, building networks, creating implementation plans, determining metrics to monitor outcomes, and drafting policy recommendations can lead to profound influences on society’s major social problems. The process and framework of the Grand Challenge Initiative can also serve to inform other social and academic movements. As the initiative advances, there is a continued need for interdisciplinary and cross-sector innovation, research and collaboration to address some of society’s grandest challenges.