Humans pollute the marine environment biologically, chemically, and physically, which can potentially drive or facilitate the emergence, proliferation, or impact of disease. This chapter synthesizes what is known about the effects of biological (e.g., wastewater), chemical (e.g., pharmaceuticals), and physical (e.g., sound/light) pollution on marine disease dynamics. The presence of these pollutants has been found to alter disease prevalence, increase host susceptibility to infection, and alter the spread and host range of different diseases. Despite the importance of the marine environment as a primary food source for humans, many complexities linking disease ecology and pollution are yet to be explored. Future investigation of these connections would benefit from an integrated approach using experimental, environmental, molecular, and pathological methods.