Lifetime prevalence and associated factors of itch with skin conditions: atopic dermatitis, psoriasis and dry skin in individuals aged > 50 years

Abstract

Abstract Background Itch, common in dermatological conditions, is often accompanied by psychological distress and reduced quality of life. However, research on the prevalence and associated factors of itch with skin conditions in general populations is limited. Objectives This cross-sectional study aimed to determine the lifetime prevalence of itch with skin conditions and to identify its associated factors in individuals aged > 50 years. Methods Participants from the Rotterdam Study, a population-based cohort, were interviewed to assess whether they had ever had an itchy skin condition, defining lifetime itch with skin conditions. Over 20 demographic, lifestyle, dermatological and nondermatological factors were recorded. Multivariable logistic regression analysis explored associations between these factors and itch with skin conditions, reported as odds ratios (ORs) with 95% confidence intervals (CIs). Results In total, 5246 eligible participants were included (age range 51–100 years, median age 67; 56.0% women). The results revealed a ­lifetime prevalence of 33.7% for itch with skin conditions. Factors significantly associated with itch were female sex (OR 1.26, 95% CI 1.11–1.43), body mass index (1.02, 1.01–1.03), self-reported atopic dermatitis (4.29, 3.74–4.92), presence of atopic dermatitis (1.97, 1.60–2.43), self-­reported psoriasis (2.31, 1.77–3.01), presence of psoriasis (2.11, 1.55–2.87), self-reported dry skin (1.95, 1.73–2.20), self-reported asthma (1.40, 1.08–1.83), renal impairment (1.45, 1.17–1.79), and clinically relevant depressive (1.85, 1.52–2.25) and anxiety symptoms (1.36, 1.11–1.66). Conclusions This study reveals a substantial one-third lifetime prevalence of itch with skin conditions in individuals aged > 50 years. Significant associations with diverse lifestyle, demographic, dermatological and, intriguingly, nondermatological factors, including renal impairment, imply additional contributors to induction or persistence of itch in individuals with skin conditions.