Pachyonychia congenita: pathogenesis of pain and approaches to treatment-Reference-Cited by-同舟云学术

Pachyonychia congenita: pathogenesis of pain and approaches to treatment

Published:2024-05-28 Issue: Volume: Page:
ISSN:0307-6938
Container-title:Clinical and Experimental Dermatology
language:en
Short-container-title:

Author:

McCarthy Rebecca L¹²^ORCID,de Brito Marianne¹²^ORCID,O’Toole Edel A¹²^ORCID

Affiliation:

1. Centre for Cell Biology and Cutaneous Research, Blizard Institute, The Faculty of Medicine and Dentistry, Queen Mary University of London , London , UK

2. Department of Dermatology, Royal London Hospital, Barts Health NHS Trust , London , UK

Abstract

Abstract Pachyonychia congenita (PC) is an autosomal dominant genodermatosis characterized by a triad of chronic severe plantar pain, focal palmoplantar keratoderma and hypertrophic nail dystrophy. Plantar pain can be debilitating and have a profound impact on quality of life. Current therapeutic options for pain in PC are limited to lifestyle adjustment and mechanical techniques, with a small subgroup of patients benefiting from oral retinoids. This review investigates the pathogenesis of pain in PC and provides a summary of the current and future therapeutic options.

Funder

LEO Foundation

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/ced/advance-article-pdf/doi/10.1093/ced/llae199/58933842/llae199.pdf

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