Effects of aging on basement membrane of tibialis anterior muscle during recovery following muscle injury in rats-Reference-Cited by-同舟云学术

Effects of aging on basement membrane of tibialis anterior muscle during recovery following muscle injury in rats

Published:2022-03-29 Issue:4 Volume:71 Page:245-248
ISSN:2050-5698
Container-title:Microscopy
language:en
Short-container-title:

Author:

Kanazawa Yuji¹²,Nagano Mamoru²,Koinuma Satoshi²,Sugiyo Shinichi³,Shigeyoshi Yasufumi²

Affiliation:

1. Department of Medical Technology and Clinical Engineering, Hokuriku University , Kanazawa 920-1180, Japan

2. Department of Anatomy and Neurobiology, Graduate School of Medical Sciences, Kindai University , Ohnohigashi, Osakasayama 589-8511, Japan

3. Department of Physical Therapy, Osaka University of Human Sciences , Shojyaku, Settsu 566-8501, Japan

Abstract

Abstract We investigated the effect of aging on the basement membrane (BM) during postinjury muscle recovery. Using a rat model, we found that aging delayed muscle fiber and BM recovery. In addition, expression of BM-related factors peaked 7 days after muscle injury among both young and older rats. Peak expression of collagen IV synthetic factors decreased with age, whereas expression of the degradative factor was unaffected by age. These results suggest that age-related delays in postinjury muscle fiber and BM recovery may be related to the suppression of collagen IV synthetic factors.

Funder

Hokuriku University Special Research Grant

Publisher

Oxford University Press (OUP)

Subject

Radiology, Nuclear Medicine and imaging,Instrumentation,Structural Biology

Link

https://academic.oup.com/jmicro/advance-article-pdf/doi/10.1093/jmicro/dfac016/43350001/dfac016.pdf

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3. Collagen IV trafficking: the inside-out and beyond story;Chioran;Dev. Biol.,2017