Tumour necrosis factor-alpha in uraemic serum promotes osteoblastic transition and calcification of vascular smooth muscle cells via extracellular signal-regulated kinases and activator protein 1/c-FOS-mediated induction of interleukin 6 expression

Author:

Zickler Daniel1,Luecht Christian12,Willy Kevin1,Chen Lei1,Witowski Janusz3,Girndt Matthias4,Fiedler Roman4,Storr Markus5,Kamhieh-Milz Julian6,Schoon Janosch78,Geissler Sven78,Ringdén Olle9,Schindler Ralf1,Moll Guido789,Dragun Duska12,Catar Rusan12

Affiliation:

1. Clinic for Nephrology and Critical Care Medicine, Charite-Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany

2. Berlin Institute of Health (BIH), Berlin, Germany

3. Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland

4. Department of Internal Medicine II, Martin-Luther-University Halle, Germany

5. Department of Research and Development, Gambro Dialysatoren GmbH, Hechingen, Germany

6. Department of Transfusion Medicine

7. Berlin-Brandenburg Center and School for Regenerative Therapies(BCRT/BSRT)

8. Julius Wolff Institute for Biomechanics and Muskuloskeletal Regeneration (JWI), Charité-Universitätsmedizin Berlin, Berlin, Germany

9. Division of Therapeutic Immunology (TIM), Department of Laboratory Medicine (LABMED), Karolinska Institutet, Stockholm, Sweden

Funder

BMBF

BCRT

German Research Foundation

DFG

Publisher

Oxford University Press (OUP)

Subject

Transplantation,Nephrology

Reference79 articles.

1. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization;Go;N Engl J Med,2004

2. Vascular calcification in chronic kidney disease: an update;Schlieper;Nephrol Dial Transplant,2016

3. Long interdialytic interval and mortality among patients receiving hemodialysis;Foley;N Engl J Med,2011

4. Cardiovascular risk and mineral bone disorder in patients with chronic kidney disease;Staude;Kidney Blood Press Res,2013

5. US renal data system 2015 annual data report: epidemiology of kidney disease in the United States;Saran;Am J Kidney Dis,2016

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