1. Laboratory of Pharmaceutical and Medicinal Chemistry (PharMedChem) , Department of Biological and Health Sciences, Federal University of Amapá, 68903-419, Macapá, Amapá, Brazil
2. Computational Laboratory of Pharmaceutical Chemistry , School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, 14040-90, Ribeirão Preto, São Paulo, Brazil
3. Departamento de Química , Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, 14040-903, Ribeirão Preto, São Paulo, Brazil
4. Metabolomics Laboratory (LabMeta , LADETEC), Instituto of Chemistry, Federal University of Rio de Janeiro (UFRJ), 21941-598 Rio de Janeiro, Rio de Janeiro, Brazil
5. Phytopharmaceutical Nanobiotechnology Laboratory (NanoFito) , Department of Biological and Health Sciences, Federal University of Amapá, 68903-419, Macapá, Amapá, Brazil
6. Laboratory of Drug Research , Department of Biological and Health Sciences, Federal University of Amapá, 68903-419, Macapá, Amapá, Brazil