Fibrostenotic Phenotype of Myofibroblasts in Crohn’s Disease is Dependent on Tissue Stiffness and Reversed by LOX Inhibition

Author:

de Bruyn Jessica R12,van den Brink Gijs R12,Steenkamer Jessica2,Buskens Christianne J3,Bemelman Willem A3,Meisner Sander2,Muncan Vanesa2,te Velde Anje A12,D’Haens Geert R1,Wildenberg Manon E12

Affiliation:

1. Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands

2. Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands

3. Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands

Funder

Netherlands Organization for Scientific Research

Publisher

Oxford University Press (OUP)

Subject

Gastroenterology,General Medicine

Reference48 articles.

1. Risk factors associated with progression to intestinal complications of Crohn’s disease in a population-based cohort;Thia;Gastroenterology,2010

2. Epidemiology and natural history of inflammatory bowel diseases;Cosnes;Gastroenterology,2011

3. Impact of the increasing use of immunosuppressants in Crohn’s disease on the need for intestinal surgery;Cosnes;Gut,2005

4. Mechanisms of fibrosis: therapeutic translation for fibrotic disease;Wynn;Nat Med,2012

5. Intestinal fibrosis is reduced by early elimination of inflammation in a mouse model of IBD: impact of a “Top-Down” approach to intestinal fibrosis in mice;Johnson;Inflamm Bowel Dis,2012

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