Four Kinds of Polymer Microspheres Prepared by the Seed Swelling Method Used to Purify the Industrial Production of Phytol-Reference-Cited by-同舟云学术

Four Kinds of Polymer Microspheres Prepared by the Seed Swelling Method Used to Purify the Industrial Production of Phytol

Published:2023-02-07 Issue: Volume: Page:
ISSN:0021-9665
Container-title:Journal of Chromatographic Science
language:en
Short-container-title:

Author:

Liu Shixiang¹²,Fang Zhipeng¹²,Li Yanan¹²,Kang Linlin¹²,Cong Hailin¹²³,Shen Youqing¹²⁴⁵,Yu Bing¹²³^ORCID

Affiliation:

1. College of Chemistry and Chemical Engineering , College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, , Qingdao 266071 , China

2. Qingdao University , College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, , Qingdao 266071 , China

3. State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University , Qingdao 266071 , China

4. Key Laboratory of Biomass Chemical Engineering of Ministry of Education , Center for Bionanoengineering, and Department of Chemical and Biological Engineering, , Hangzhou, Zhejiang 310027 , China

5. Zhejiang University , Center for Bionanoengineering, and Department of Chemical and Biological Engineering, , Hangzhou, Zhejiang 310027 , China

Abstract

Abstract Four monodisperse porous polymer microspheres were successfully prepared by seed emulsion polymerization and used as stationary phases for HPLC and preparative high-performance liquid chromatography (Prep-HPLC). All four polymer microspheres(polystyrene–polystyrene (PS-PS), polystyrene-poly(glycidyl methylate) (PS-PGMA), polystyrene-poly(methyl methylate) and poly(glycidyl methylate)–poly(glycidyl methylate) were used for filling HPLC empty columns. According to the analysis results of the HPLC column, PS-PS and PS-PGMA microspheres were screened out as the stationary phase of Prep-HPLC. The industrial-grade phytol was successfully separated and purified, and the purity of the final phytol was as high as 99%. The two types of polymer microspheres have been applied to industrial-grade phytol purification and have been used in factories.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Science and Technology Planing Project of South District of Qingdao City

State Key Laboratory of BioFibers and EcoTextiles of Qingdao University

High Level Discipline Project of Shandong Province

Publisher

Oxford University Press (OUP)

Subject

General Medicine,Analytical Chemistry

Link

https://academic.oup.com/chromsci/advance-article-pdf/doi/10.1093/chromsci/bmad006/49117660/bmad006.pdf