Combined rituximab and belimumab to treat recalcitrant epidermolysis bullosa aquisita associated with systemic lupus erythematosus

Author:

Tull Thomas J1ORCID,Benton Emma C1,Semkova Kristina1,Watson Natalie A2,Mee John B1,Lopez Begona3,Setterfield Jane1,Carey Barbara1,Ahmad Sajjad4,Robbie Scott J5,Groves Richard W1,Sanna Giovanni3,D’Cruz David P3

Affiliation:

1. St John’s Institute of Dermatology

2. Ear, Nose and Throat Department

3. Louise Coote Lupus Unit

4. Moorfields Eye Hospital NHS Foundation Trust , London , UK

5. Department of Ophthalmology, Guy’s and St Thomas’ NHS Foundation Trust

Abstract

We report two cases of recalcitrant epidermolysis bullosa aquisita with associated systemic lupus erythematosus treated with combination rituximab and belimumab therapy. This resulted in the complete resolution of cutaneous lesions and a partial response of the mucosal lesions. These cases support the use of combined rituximab and belimumab for the treatment of recalcitrant immunobullous disease.

Publisher

Oxford University Press (OUP)

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