Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension

Author:

Krishnan Shalini M1,Ling Yeong H1,Huuskes Brooke M2,Ferens Dorota M1,Saini Narbada2,Chan Christopher T1,Diep Henry12,Kett Michelle M3,Samuel Chrishan S1,Kemp-Harper Barbara K1,Robertson Avril A B4,Cooper Matthew A4,Peter Karlheinz5,Latz Eicke678,Mansell Ashley S9,Sobey Christopher G12,Drummond Grant R12,Vinh Antony12

Affiliation:

1. Department of Pharmacology, Monash University, Clayton, Victoria, Australia

2. Department of Physiology, Anatomy and Microbiology, La Trobe University, Melbourne Campus, Bundoora, Victoria, Australia

3. Department of Physiology, Monash University, Clayton, Victoria, Australia

4. Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia

5. Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

6. Institute of Innate Immunity, University Hospital Bonn, University of Bonn, Bonn, Germany

7. Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, USA

8. German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

9. Hudson Institute of Medical Research, Clayton, Victoria, Australia

Funder

National Health and Medical Research Council of Australia

European Research Council InflammAct

Deutsche Forschungsgemeinschaft

Publisher

Oxford University Press (OUP)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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