MGMT promoter methylation status testing to guide therapy for glioblastoma: refining the approach based on emerging evidence and current challenges

Author:

Mansouri Alireza1,Hachem Laureen D1,Mansouri Sheila2,Nassiri Farshad12,Laperriere Normand J3,Xia Daniel4ORCID,Lindeman Neal I5,Wen Patrick Y6,Chakravarti Arnab7,Mehta Minesh P8,Hegi Monika E9,Stupp Roger10,Aldape Kenneth D11,Zadeh Gelareh1212

Affiliation:

1. Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada

2. MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada

3. Department of Radiation Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada

4. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

5. Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA

6. Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

7. Radiation Oncology, The Ohio State University College of Medicine, Columbus, Ohio, USA

8. Department of Radiation Oncology, Miami Cancer Institute, Miami, Florida, USA

9. Department of Clinical Neurosciences, Lausanne University Hospital, Lausanne, Switzerland

10. Malnati Brain Tumor Institute of the Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

11. Department of Laboratory Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

12. Division of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Neurology (clinical),Oncology

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