The Role of Maternally Acquired Antibody in Providing Protective Immunity Against Nontyphoidal Salmonella in Urban Vietnamese Infants: A Birth Cohort Study-Reference-Cited by-同舟云学术

The Role of Maternally Acquired Antibody in Providing Protective Immunity Against Nontyphoidal Salmonella in Urban Vietnamese Infants: A Birth Cohort Study

Published:2018-10-12 Issue:2 Volume:219 Page:295-304
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

de Alwis Ruklanthi¹²³⁴,Tu Le Thi Phuong¹,Quynh Nhi Le Thi¹,Thompson Corinne N¹²⁵,Anders Katherine L⁶,Van Thuy Nguyen Thi¹,Hieu Nguyen Trong⁷,Vi Lu Lan⁸,Chau Nguyen Van Vinh⁸,Duong Vu Thuy¹,Chau Tran Thi Hong¹,Tuyen Ha Thanh¹,Nga Tran Vu Thieu¹,Minh Pham Van¹,Tan Trinh Van¹,Thu Trang Nguyen Hoang¹,Nhu Tran Do Hoang¹,Thwaites Guy E¹²,Simmons Cameron¹²⁹,Baker Stephen¹²¹⁰

Affiliation:

1. Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam

2. Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom

3. Program in Emerging Infectious Diseases, Duke University–National University of Singapore (Duke-NUS) Medical School, Singapore

4. Viral Research and Experimental Medicine Centre, SingHealth Duke-NUS Academic Medical Centre, Singapore

5. London School of Hygiene and Tropical Medicine, London, United Kingdom

6. School of Biological Sciences, Monash University, Victoria, Australia

7. Hung Vuong Hospital, Ho Chi Minh City, Vietnam

8. Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

9. Department of Microbiology and Immunology, University of Melbourne, Melbourne, Australia

10. Department of Medicine, University of Cambridge, Cambridge, United Kingdom

Abstract

We found a high transfer ratio of anti-nontyphoidal Salmonella (NTS) antibodies from mothers to infants. Furthermore, despite a high seroincidence of NTS in infants, maternally acquired antibodies provided protection from seroconversion. Therefore, we propose prenatal immunization against NTS as a possible strategy for protecting infants from NTS disease.

Funder

Wellcome Trust

Royal Society

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

http://academic.oup.com/jid/article-pdf/219/2/295/27276239/jiy501.pdf

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