Planning and Analyzing a Low-Biomass Microbiome Study: A Data Analysis Perspective

Author:

Austin George I12ORCID,Korem Tal23ORCID

Affiliation:

1. Department of Biomedical Informatics

2. Program for Mathematical Genomics, Department of Systems Biology

3. Department of Obstetrics and Gynecology, Columbia University Irving Medical Center , New York, New York

Abstract

Abstract As investigations of low-biomass microbial communities have become more common, so too has the recognition of major challenges affecting these analyses. These challenges have been shown to compromise biological conclusions and have contributed to several controversies. Here, we review some of the most common and influential challenges in low-biomass microbiome research. We highlight key approaches to alleviate these potential pitfalls, combining experimental planning strategies and data analysis methods.

Funder

Program for Mathematical Genomics at Columbia University

National Institutes of Health

Publisher

Oxford University Press (OUP)

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