Susceptibility and Attenuated Transmissibility of SARS-CoV-2 in Domestic Cats-Reference-Cited by-同舟云学术

Susceptibility and Attenuated Transmissibility of SARS-CoV-2 in Domestic Cats

Published:2021-02-19 Issue:8 Volume:223 Page:1313-1321
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Bao Linlin¹²,Song Zhiqi¹²,Xue Jing¹²,Gao Hong¹²,Liu Jiangning¹²,Wang Jie¹²,Guo Qian²,Zhao Binbin¹²,Qu Yajin¹²,Qi Feifei¹²,Gong Shuran¹²,Liu Mingya¹²,Lv Qi¹²,Li Dan¹²,Han Yunlin¹²,Zhao Wenjie¹²,Deng Shoulong²,Liu Yunpeng²,Xiang Zhiguang²^ORCID,Yang Bochao²,Deng Wei¹²,Yu Haisheng¹²,Cong Zhe¹²,Wei Qiang¹²,Xu Jianguo³,Gao George F⁴,Qin Chuan¹²

Affiliation:

1. Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China

2. NHC Key Laboratory of Human Disease Comparative Medicine, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China

3. National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China

4. Chinese Center for Disease Control and Prevention, Beijing, China

Abstract

Abstract Domestic cats, an important companion animal, can be infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This has aroused concern regarding the ability of domestic cats to spread the virus that causes coronavirus disease 2019. We systematically demonstrated the pathogenesis and transmissibility of SARS-CoV-2 in cats. Serial passaging of the virus between cats dramatically attenuated the viral transmissibility, likely owing to variations of the amino acids in the receptor-binding domain sites of angiotensin-converting enzyme 2 between humans and cats. These findings provide insight into the transmissibility of SARS-CoV-2 in cats and information for protecting the health of humans and cats.

Funder

National Mega Projects of China for Major Infectious Diseases

CAMS Initiative for Innovative Medicine of China

National Key Research and Development Project of China

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

http://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiab104/36320401/jiab104.pdf

Reference23 articles.

1. Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2;Shi;Science,2020