Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 via Close Contact and Respiratory Droplets Among Human Angiotensin-Converting Enzyme 2 Mice

Author:

Bao Linlin1,Gao Hong1,Deng Wei1,Lv Qi1,Yu Haisheng1,Liu Mingya1,Yu Pin1,Liu Jiangning1,Qu Yajin1,Gong Shuran1,Lin Kaili1,Qi Feifei1,Xu Yanfeng1,Li Fengli1,Xiao Chong1,Xue Jing1,Song Zhiqi1,Xiang Zhiguang1ORCID,Wang Guanpeng1,Wang Shunyi1,Liu Xing1,Zhao Wenjie1,Han Yunlin1,Wei Qiang1,Qin Chuan1

Affiliation:

1. NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China

Abstract

Abstract We simulated 3 transmission modes, including close-contact, respiratory droplets and aerosol routes, in the laboratory. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be highly transmitted among naive human angiotensin-converting enzyme 2 (hACE2) mice via close contact because 7 of 13 naive hACE2 mice were SARS-CoV-2 antibody seropositive 14 days after being introduced into the same cage with 3 infected-hACE2 mice. For respiratory droplets, SARS-CoV-2 antibodies from 3 of 10 naive hACE2 mice showed seropositivity 14 days after introduction into the same cage with 3 infected-hACE2 mice, separated by grids. In addition, hACE2 mice cannot be experimentally infected via aerosol inoculation until continued up to 25 minutes with high viral concentrations.

Funder

National Key Research and Development Project of China

Innovative Medicine of China

National Mega projects of China for Major Infectious Diseases

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Reference4 articles.

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2. Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection;Yang;Comp Med,2007

3. Novel avian-origin human influenza A(H7N9) can be transmitted between ferrets via respiratory droplets;Xu;J Infect Dis,2014

4. Study of SARS transmission via liquid droplets in air;Wang;J Biomech Eng,2005

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