Clinical Phenotypes and Molecular Characteristics of Respiratory Syncytial Virus in Adults: A Monocentric Prospective Study Between 2019 and 2022-Reference-Cited by-同舟云学术

Clinical Phenotypes and Molecular Characteristics of Respiratory Syncytial Virus in Adults: A Monocentric Prospective Study Between 2019 and 2022

Published:2023-10-31 Issue: Volume: Page:
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Bay Pierre¹²³^ORCID,Loegel Cloé³,Ly Arnaud³,Soulier Alexandre³⁴,N’Debi Mélissa⁵,Seng Sarah⁵,Kassasseya Christian⁶,Rodriguez Christophe³⁴⁵,Pawlotsky Jean-Michel³⁴⁵,de Prost Nicolas¹²^ORCID,Fourati Slim³⁴

Affiliation:

1. Service de Médecine Intensive Réanimation, DMU Médecine, Hôpitaux Universitaires Henri Mondor, Assistance Publique–Hôpitaux de Paris , Créteil , France

2. GRC CARMAS, Faculté de Santé de Créteil, Université Paris-Est-Créteil , Créteil , France

3. Équipe “Virus, Hépatologie, Cancer,” INSERM U955, Université Paris-Est-Créteil , Créteil , France

4. Département de Microbiologie, Hôpitaux Universitaires Henri Mondor, Assistance Publique–Hôpitaux de Paris , Créteil , France

5. Plateforme de Génomique, Hôpitaux Universitaires Henri Mondor, Assistance Publique–Hôpitaux de Paris, Institut Mondor de Recherche Biomédicale , Créteil , France

6. Service d’Accueil des Urgences, Hôpitaux Universitaires Henri Mondor, Assistance Publique–Hôpitaux de Paris , Créteil , France

Abstract

Abstract Respiratory syncytial virus (RSV) infection is a major cause of pneumonia in adults. Little is known on the viral genetic diversity and the associated clinical phenotypes in this population. This single-center prospective cohort study included RSV-infected patients hospitalized between January 2019 and December 2022. Of 100 patients, including 41 with severe infection, 72 were infected with RSV-B. RSV genome sequencing showed no clustering according to severity. Patients infected with RSV-B with risk factors for severe pneumonia had significantly higher fusion protein diversity scores. No amino acid substitutions conferring resistance to nirsevimab were detected.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

https://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiad479/53447169/jiad479.pdf

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