Monoclonal Antibody Protects Against Acinetobacter baumannii Infection by Enhancing Bacterial Clearance and Evading Sepsis

Author:

Nielsen Travis B1,Pantapalangkoor Paul1,Luna Brian M1,Bruhn Kevin W1,Yan Jun1,Dekitani Ken1,Hsieh Sarah1,Yeshoua Brandon1,Pascual Bryan1,Vinogradov Evgeny2,Hujer Kristine M34,Domitrovic T Nicholas34,Bonomo Robert A345,Russo Thomas A6,Lesczcyniecka Magda7,Schneider Thomas7,Spellberg Brad1

Affiliation:

1. Department of Medicine and Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles;

2. National Research Council Canada, Ottowa, Ontario;

3. Louis Stokes Cleveland Veterans Affairs Medical Center, and

4. Department of Medicine and

5. Departments of Pharmacology, Molecular Biology and Microbiology, Biochemistry, and Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio;

6. Veterans Administration Western New York Healthcare System, and the Departments of Medicine and Microbiology and Immunology, and Witebsky Center for Microbial Pathogenesis, University at Buffalo–State University of New York, Buffalo, New York; and

7. STC Biologics, Inc, Cambridge, Massachusetts

Funder

National Institutes of Health

National Institute of Allergy and Infectious Diseases

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Reference31 articles.

1. Global challenge of multidrug-resistant Acinetobacter baumannii;Perez;Antimicrob Agents Chemother,2007

2. Global spread of carbapenem-resistant Acinetobacter baumannii;Higgins;J Antimicrob Chemother,2010

3. Extensively drug-resistant Acinetobacter baumannii;Doi;Emerg Infect Dis,2009

4. The FDA reboot of antibiotic development;Shlaes;Antimicrob Agents Chemother,2013

5. The value of single-pathogen antibacterial agents;Spellberg;Nat Rev Drug Discov,2013

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