Insights From Studies of the Genetics, Pathogenesis, and Immunogenicity of the Varicella Vaccine

Author:

Arvin Ann M1

Affiliation:

1. Departments of Pediatrics and Microbiology and Immunology, Stanford University School of Medicine , Stanford, California , USA

Abstract

Abstract While the varicella vaccine was created with approaches established for other live attenuated viral vaccines, novel methods to probe virus-host interactions have been used to explore the genetics, pathogenesis, and immunogenicity of the vaccine compared to wild-type varicella-zoster virus (VZV). As summarized here, a mechanism-based understanding of the safety and efficacy of the varicella vaccine has been achieved through these investigations.

Funder

Stanford University

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

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