Seroreversion to <i>Chlamydia trachomatis</i> Pgp3 Antigen Among Children in a Hyperendemic Region of Amhara, Ethiopia-Reference-Cited by-同舟云学术

Seroreversion to Chlamydia trachomatis Pgp3 Antigen Among Children in a Hyperendemic Region of Amhara, Ethiopia

Published:2023-12-22 Issue: Volume: Page:
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Tedijanto Christine¹^ORCID,Aragie Solomon²^ORCID,Gwyn Sarah³^ORCID,Wittberg Dionna M¹^ORCID,Zeru Taye⁴^ORCID,Tadesse Zerihun²,Chernet Ambahun²,Thompson Isabel J B¹,Nash Scott D⁵^ORCID,Lietman Thomas M¹⁶⁷^ORCID,Martin Diana L³,Keenan Jeremy D¹⁶^ORCID,Arnold Benjamin F¹⁶^ORCID

Affiliation:

1. Francis I. Proctor Foundation, University of California, San Francisco , San Francisco, California , USA

2. The Carter Center Ethiopia , Addis Ababa , Ethiopia

3. Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention , Atlanta, Georgia , USA

4. Amhara Public Health Institute , Bahir Dar , Ethiopia

5. The Carter Center , Atlanta, Georgia , USA

6. Department of Ophthalmology, University of California, San Francisco , San Francisco, California , USA

7. Department of Epidemiology and Biostatistics, University of California, San Francisco , San Francisco, California , USA

Abstract

Abstract Monitoring trachoma transmission with antibody data requires characterization of decay in IgG to Chlamydia trachomatis antigens. In a 3-year longitudinal cohort in a high-transmission setting, we estimated a median IgG half-life of 3 years and a seroreversion rate of 2.5 per 100 person-years (95% confidence interval, 1.6–3.5). Clinical Trials Registration. NCT02754583.

Funder

National Institute of Allergy and Infectious Disease

National Eye Institute

Abbott

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

https://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiad602/55547556/jiad602.pdf

Reference14 articles.

1. The relationship between active trachoma and ocular Chlamydia trachomatis infection before and after mass antibiotic treatment;Ramadhani;PLoS Negl Trop Dis,2016

2. The use of serology for trachoma surveillance: current status and priorities for future investigation;Martin;PLoS Negl Trop Dis,2020

3. CT694 and pgp3 as serological tools for monitoring trachoma programs;Goodhew;PLoS Negl Trop Dis,2012

4. Serology for trachoma surveillance after cessation of mass drug administration;Martin;PLoS Negl Trop Dis,2015

5. Population-based prevalence of Chlamydia trachomatis infection and antibodies in four districts with varying levels of trachoma endemicity in Amhara, Ethiopia;Nash;Am J Trop Med Hyg,2021