Trypomastigote Excretory Secretory Antigen Blot Is Associated With Trypanosoma cruzi Load and Detects Congenital T. cruzi Infection in Neonates, Using Anti–Shed Acute Phase Antigen Immunoglobulin M-Reference-Cited by-同舟云学术

Trypomastigote Excretory Secretory Antigen Blot Is Associated With Trypanosoma cruzi Load and Detects Congenital T. cruzi Infection in Neonates, Using Anti–Shed Acute Phase Antigen Immunoglobulin M

Published:2018-09-25 Issue:4 Volume:219 Page:609-618
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Noazin Sassan¹,Lee Jessica A²,Malaga Edith S³,Valencia Ayala Edward³,Condori Beth J³,Roca Cristian³,Lescano Andres G⁴,Bern Caryn⁵,Castillo Walter³,Mayta Holger¹³⁶,Menduiña Maria Carmen⁷,Verastegui Manuela R³⁶,Tinajeros Freddy⁸,Gilman Robert H¹³⁶,Miranda-Schaeubinger Monica,Chakravarti Indira,Ferriss Ellen L,Chavez Clariza,Velarde Jean Karla,Urquizu Federico,Gorena Mirko,Bowman Natalie,Hinojosa Edith,

Affiliation:

1. Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

2. School of Medical Sciences, University of Manchester, United Kingdom

3. Infectious Diseases Research Laboratory, Department of Cellular Molecular Sciences, School of Science and Philosophy

4. Emerge, Emerging Diseases and Climate Change Research Unit, School of Public Health and Administration, Universidad Peruana Cayetano Heredia

5. Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco

6. Asociación Benéfica PRISMA, Lima, Peru

7. Percy Boland Maternity Hospital

8. Asociación Benéfica PRISMA, Santa Cruz, Bolivia

Abstract

We studied immunoglobulin M–specific shed acute phase antigen bands for diagnosing congenital Chagas disease in newborns. With quantitative polymerase chain reaction as the gold standard, sensitivity was 80%, and specificities were 94% and 100% in areas of endemicity and nonendemicity, respectively.

Funder

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

http://academic.oup.com/jid/article-pdf/219/4/609/30123220/jiy562.pdf

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