Seasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation

Author:

Piñana Jose Luis12,Xhaard Aliénor3,Tridello Gloria4,Passweg Jakob5,Kozijn Anne6,Polverelli Nicola7,Heras Inmaculada8,Perez Ariadna9,Sanz Jaime12,Berghuis Dagmar10,Vázquez Lourdes11,Suárez-Lledó María12,Itäla-Remes Maija13,Ozcelik Tulay14,Iturrate Basarán Isabel15,Karakukcu Musa16,Al Zahrani Mohsen17,Choi Goda18,Cuesta Casas Marián Angeles19,Batlle Massana Montserrat20,Viviana Amato21,Blijlevens Nicole22,Ganser Arnold23,Kuskonmaz Baris24,Labussière-Wallet Hélène25,Shaw Peter J26,Yegin Zeynep Arzu27,González-Vicent Marta28,Rocha Vanderson29,Ferster Alina30,Knelange Nina3,Navarro David8,Mikulska Malgorzata31,de la Camara Rafael15,Styczynski Jan32

Affiliation:

1. Hematology Division, Hospital Universitario y Politécnico La Fe, Valencia, Spain

2. CIBERONC, Instituto Carlos III, Madrid, Spain

3. Service d’Hématologie-Greffe, Hôpital Saint-Louis, Université Paris-Diderot, Paris, France

4. Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

5. University Hospital Basel, Basel, Switzerland

6. European Society for Blood and Marrow Transplantation Data Office Leiden, Leiden, The Netherlands

7. Unit of Blood Diseases and Stem Cell Transplantation, University of Brescia Azienda Socio Sanitaria Territoriale Spedali Civili di Brescia, Brescia, Italy

8. Hematology Division, Hospital Morales Meseguer, Murcia, Spain

9. Hematology Division, Hospital Clínico de Valencia, Valencia, Spain

10. Willem Alexander Children’s Hospital/Leiden University Medical Center, Leiden, The Netherlands

11. Hematology Division, Hospital Universitario de Salamanca, Salamanca, Spain

12. Hematology Division, Hospital Clínic, Barcelona, Spain

13. Turku University Hospital, Turku, Finland

14. Demiroglu Bilim University, Istanbul, Turkey

15. Hematology Division, Hospital de la Princesa, Madrid, Spain

16. Erciyes University, Faculty of Medicine, Erciyes Pediatric Bone Marrow Transplant Center, Kayseri, Turkey

17. King Abdulaziz Medical City, Riyadh, Saudi Arabia

18. University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

19. Hematology Division, Hospital Regional de Málaga, Malaga, Spain

20. Hematology Division, Instituto Catalan de Oncologia-Hospital Germans Trias i Pujol, Barcelona, Spain

21. Universita Cattolica S. Cuore, Rome, Italy

22. Radboud University Medical Center, Nijmegen, The Netherlands

23. Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation. Hannover Medical School, Hannover, Germany

24. Hacettepe University Children’s Hospital, Ankara, Turkey

25. Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France

26. Children’s Hospital at Westmead, Sydney, Australia

27. Gazi University Faculty of Medicine, Ankara, Turkey

28. Pediatric Division, Niño Jesus Children’s Hospital, Madrid, Spain

29. Hospital Sirio-Libanes, São Paulo, Brazil

30. Children’s University Hospital Queen Fabiola, Université Libre de Bruxelles, Brussels, Belgium

31. University of Genoa (Dipartimento di Scienze della Salute) and Istituto Nazionale per la Ricerca sul Cancro Ospedale Policlinico San Martino, Genova, Italy

32. Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University Torun Uniwersytet Mikołaja Kopernika, University Hospital, Bydgoszcz, Poland

Abstract

Abstract Background Little is known about characteristics of seasonal human coronaviruses (HCoVs) (NL63, 229E, OC43, and HKU1) after allogeneic stem cell transplantation (allo-HSCT). Methods This was a collaborative Spanish and European bone marrow transplantation retrospective multicenter study, which included allo-HSCT recipients (adults and children) with upper respiratory tract disease (URTD) and/or lower respiratory tract disease (LRTD) caused by seasonal HCoV diagnosed through multiplex polymerase chain reaction assays from January 2012 to January 2019. Results We included 402 allo-HSCT recipients who developed 449 HCoV URTD/LRTD episodes. Median age of recipients was 46 years (range, 0.3–73.8 years). HCoV episodes were diagnosed at a median of 222 days after transplantation. The most common HCoV subtype was OC43 (n = 170 [38%]). LRTD involvement occurred in 121 episodes (27%). HCoV infection frequently required hospitalization (18%), oxygen administration (13%), and intensive care unit (ICU) admission (3%). Three-month overall mortality after HCoV detection was 7% in the whole cohort and 16% in those with LRTD. We identified 3 conditions associated with higher mortality in recipients with LRTD: absolute lymphocyte count <0.1 × 109/mL, corticosteroid use, and ICU admission (hazard ratios: 10.8, 4.68, and 8.22, respectively; P < .01). Conclusions Seasonal HCoV after allo-HSCT may involve LRTD in many instances, leading to a significant morbidity.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

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