Unintended HIV-1 Transmission to a Sex Partner in a Study of a Therapeutic Vaccine Candidate-Reference-Cited by-同舟云学术

Unintended HIV-1 Transmission to a Sex Partner in a Study of a Therapeutic Vaccine Candidate

Published:2019-02-16 Issue:Supplement_1 Volume:220 Page:S5-S6
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Lelièvre Jean-Daniel¹²³^ORCID,Hocqueloux Laurent⁴

Affiliation:

1. Vaccine Research Institute, équipe 16, Faculté de Médecine, Université Paris Est Créteil, Groupe Henri-Mondor Albert-Chenevier, Créteil

2. INSERM U955, équipe 16, Faculté de Médecine, Université Paris Est Créteil, Groupe Henri-Mondor Albert-Chenevier, Créteil

3. Assistance Publique-Hôpitaux de Paris, Service d’Immunologie Clinique, Groupe Henri-Mondor Albert-Chenevier, Créteil

4. Centre Hospitalier Régional d’Orléans, Orléans, France

Abstract

Abstract We report a case of sexual transmission of human immunodeficiency virus (HIV) that occurred during treatment discontinuation in a therapeutic vaccine trial, following oral sex. Transmission occurred even though the index participant was an HIV/AIDS activist, particularly well informed about the risks and modalities of transmission. This case report highlights the risk of secondary transmission of HIV during cessation of treatment in HIV cure–related trials.

Funder

Inserm-ANRS and the Investissements d’Avenir program

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

http://academic.oup.com/jid/article-pdf/220/Supplement_1/S5/28896287/jiz012.pdf

Reference2 articles.

1. Preliminary safety results from VRI02 ANRS 149 Light (Lipopeptide and DNA GTU HIV Therapeutic Trial) [abstract P27.09];Levy

2. Preexposure prophylaxis for mitigating risk of HIV transmission during HIV cure–related clinical trials with a treatment interruption;Lelièvre

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