Natural Killer Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Against SARS-CoV-2 After Natural Infection Is More Potent Than After Vaccination-Reference-Cited by-同舟云学术

Natural Killer Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Against SARS-CoV-2 After Natural Infection Is More Potent Than After Vaccination

Published:2022-03-22 Issue:10 Volume:225 Page:1688-1693
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Rieke Gereon J¹,van Bremen Kathrin¹,Bischoff Jenny¹^ORCID,ToVinh Michael¹,Monin Malte B¹,Schlabe Stefan¹²,Raabe Jan¹,Kaiser Kim M¹,Finnemann Claudia¹,Odainic Alexandru³⁴,Kudaliyanage Anushka³,Latz Eicke³,Strassburg Christian P¹,Boesecke Christoph¹²,Schmidt Susanne V³,Krämer Benjamin¹,Rockstroh Jürgen K¹²,Nattermann Jacob¹²

Affiliation:

1. Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany

2. German Centre for Infection Research, Partner-site Cologne-Bonn, Bonn, Germany

3. Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany

4. Department of Microbiology and Immunology, Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia

Abstract

Abstract We compared the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike-specific antibodies to induce natural killer cell-mediated antibody-dependent cellular cytotoxicity (ADCC) in patients with natural infection and vaccinated persons. Analyzing plasma samples from 39 coronavirus disease 2019 (COVID-19) patients and 11 vaccinated individuals, significant induction of ADCC could be observed over a period of more than 3 months in both vaccinated and recovered individuals. Although plasma antibody concentrations were lower in recovered patients, we found antibodies elicited by natural infection induced a significantly stronger ADCC response compared to those induced by vaccination, which may affect protection conferred by vaccination.

Funder

Deutsche Forschungsgemeinschaft

Hector Foundation

University of Bonn

Federal Ministry of Education and Research

Deutsche Leberstiftung

DZIF

Hector Stiftung

NEAT ID

Publisher

Oxford University Press (OUP)

Subject