Genome-wide analysis of disease progression in age-related macular degeneration

Author:

Yan Qi1,Ding Ying2,Liu Yi12,Sun Tao12,Fritsche Lars G3,Clemons Traci4,Ratnapriya Rinki5,Klein Michael L6,Cook Richard J7,Liu Yu8,Fan Ruzong9,Wei Lai8,Abecasis Gonçalo R3,Swaroop Anand5,Chew Emily Y10,Weeks Daniel E211,Chen Wei1211ORCID,

Affiliation:

1. Division of Pulmonary Medicine, Allergy and Immunology, Department of Pediatrics, Children’s Hospital of Pittsburgh of UPMC University of Pittsburgh, Pittsburgh, PA 15224, USA,

2. Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA

3. Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA

4. The Emmes Corporation, Rockville, MD 20850, USA

5. Neurobiology Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA

6. Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA

7. Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON N2L 3G1, Canada

8. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong Province 510030, China

9. Department of Biostatistics, Bioinformatics, and Biomathematics, Georgetown University Medical Center, Washington, DC 20007, USA

10. Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA

11. Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA

Funder

National Institutes of Health

National Eye Institute

Publisher

Oxford University Press (OUP)

Subject

Genetics(clinical),Genetics,Molecular Biology,General Medicine

Reference24 articles.

1. The age-related eye disease study (AREDS): design implications. AREDS report no. 1;Age-Related Eye Disease Study Research;Control. Clin. Trials,1999

2. Seven new loci associated with age-related macular degeneration;Fritsche;Nat. Genet,2013

3. A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants;Fritsche;Nat. Genet,2016

4. Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration;Chen;Proc. Natl. Aacd Sci. U.S.A,2010

5. Association of CFH Y402H and LOC387715 A69S with progression of age-related macular degeneration;Seddon;JAMA,2007

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