Deletion size analysis of 1680 22q11.2DS subjects identifies a new recombination hotspot on chromosome 22q11.2

Author:

Guo Tingwei1,Diacou Alexander1,Nomaru Hiroko1,McDonald-McGinn Donna M2,Hestand Matthew3,Demaerel Wolfram3,Zhang Liangtian1,Zhao Yingjie1,Ujueta Francisco1,Shan Jidong1,Montagna Cristina1,Zheng Deyou145,Crowley Terrence B2,Kushan-Wells Leila6,Bearden Carrie E6,Kates Wendy R7,Gothelf Doron89,Schneider Maude10,Eliez Stephan10,Breckpot Jeroen3,Swillen Ann3,Vorstman Jacob11,Zackai Elaine2,Benavides Gonzalez Felipe12,Repetto Gabriela M12,Emanuel Beverly S2,Bassett Anne S1314,Vermeesch Joris R3,Marshall Christian R14,Morrow Bernice E1,

Affiliation:

1. Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA

2. Division of Human Genetics, Children’s Hospital of Philadelphia and Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA

3. Center for Human Genetics, Katholieke University Leuven (KULeuven), Leuven, Belgium

4. Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA

5. Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA

6. Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA, USA

7. Department of Psychiatry and Behavioral Sciences, and Program in Neuroscience, SUNY Upstate Medical University, Syracuse, NY, USA

8. Sackler Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel

9. Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel

10. Developmental Imaging and Psychopathology Lab, University of Geneva School of Medicine, Geneva, Switzerland

11. Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands

12. Center for Genetics and Genomics, Facultad de Medicina, Clinica Alemana Universidad del Desarrollo, Santiago, Chile

13. Center for Addiction and Mental Health, Toronto General Hospital and the University of Toronto, Toronto, Canada

14. Department of Pediatric Laboratory Medicine and Laboratory of Medicine and Pathobiology, The Hospital for Sick Children and University of Toronto, Toronto, Canada

Funder

NIH

Canadian Institutes of Health Research

Swiss National Science Foundation

Publisher

Oxford University Press (OUP)

Subject

Genetics(clinical),Genetics,Molecular Biology,General Medicine

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