Failure to Validate a Multivariable Clinical Prediction Model to Identify Pediatric Intensive Care Unit Patients at High Risk for Candidemia

Author:

Fisher Brian T.1234,Ross Rachael K.12,Roilides Emmanuel5,Palazzi Debra L.6,Abzug Mark J.7,Hoffman Jill A.8,Berman David M.9,Prasad Priya A.10,Localio A. Russell234,Steinbach William J.11,Vogiatzi Lambrini12,Dutta Ankhi6,Zaoutis Theoklis E.1234

Affiliation:

1. Division of Infectious Diseases

2. the Center for Pediatric Clinical Effectiveness, The Children's Hospital of Philadelphia, Pennsylvania

3. Department of Pediatrics

4. The Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia

5. Infectious Diseases Unit, 3rd Department of Pediatrics, Aristotle University School of Health Sciences and Hippokration Hospital, Thessaloniki, Greece

6. Infectious Diseases Section, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston

7. University of Colorado School of Medicine and Children's Hospital Colorado, Aurora

8. Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California

9. All Children's Hospital, St. Petersburg, Florida

10. Department of Epidemiology and Biostatistics, University of California San Francisco

11. Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina

12. Pediatric Intensive Care Unit, Hippokration General Hospital, Thessaloniki, Greece

Abstract

Abstract We attempted to validate a previously derived clinical prediction rule for candidemia in the pediatric intensive care unit. This multicenter case control study did not identify significant association of candidemia with most of the previously identified predictors. Additional study in larger cohorts with other predictor variables is needed.

Funder

NIH

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology, and Child Health

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