Application of the Bacterial Meningitis Score for Infants Aged 0 to 60 Days

Author:

Rees Chris A1,Cruz Andrea T2,Freedman Stephen B3,Mahajan Prashant4,Uspal Neil G5,Okada Pamela6,Aronson Paul L7,Thompson Amy D8,Ishimine Paul T9,Schmidt Suzanne M10,Kuppermann Nathan11,Nigrovic Lise E1,

Affiliation:

1. Division of Emergency Medicine, Boston Children’s Hospital, Harvard Medical School, Massachusetts

2. Department of Pediatrics, Sections of Emergency Medicine and Infectious Diseases, Baylor College of Medicine, Houston, Texas

3. Department of Pediatrics, Sections of Pediatric Emergency Medicine and Gastroenterology, Alberta Children’s Hospital and Cumming School of Medicine, University of Calgary, Canada

4. Departments of Emergency Medicine and Pediatrics, Mott Children’s Hospital, University of Michigan, Ann Arbor

5. Division of Pediatric Emergency Medicine, Department of Pediatrics, Seattle Children’s Hospital, University of Washington, Dallas

6. Department of Pediatrics, Division of Pediatric Emergency Medicine, University of Texas Southwestern Medical Center, Dallas

7. Departments of Pediatrics and Emergency Medicine, Yale School of Medicine, New Haven, Connecticut

8. Departments of Pediatrics and Emergency Medicine, Nemours/Alfred I. duPont Hospital for Children, Wilmington, Delaware

9. Departments of Emergency Medicine and Pediatrics, Rady Children’s Hospital, University of California, San Diego School of Medicine, IL

10. Division of Emergency Medicine, Department of Pediatrics, Ann and Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine, IL

11. University of California Davis Health and the University of California Davis School of Medicine, Sacramento

Abstract

Abstract In 4292 infants aged ≤60 days with cerebrospinal fluid (CSF) pleocytosis, the bacterial meningitis score had excellent sensitivity (121 of 121 [100.0%] [95% confidence interval, 96.5%–100.0%]) but low specificity (66 of 4171 [1.6%] [95% confidence interval, 1.3%–2.0%]) and therefore should not be applied clinically to infants in this age group.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology and Child Health

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