Hydroxyurea in Sickle Cell Disease and Invasive Bacterial Infections: A Case–Control Study-Reference-Cited by-同舟云学术

Hydroxyurea in Sickle Cell Disease and Invasive Bacterial Infections: A Case–Control Study

Published:2024-07-06 Issue: Volume: Page:
ISSN:2048-7207
Container-title:Journal of the Pediatric Infectious Diseases Society
language:en
Short-container-title:

Author:

Pascault Alice¹,Koehl Bérengère¹²³^ORCID,Brousse Valentine¹²³,Benkerrou Malika¹²,Gaschignard Jean⁴⁵

Affiliation:

1. Department of Pediatrics, Assistance Publique Hôpitaux De Paris , Paris , France

2. Department of Child Haematology, Reference Center for Sickle Cell Disease, Robert-Debré University Hospital , Paris , France

3. Laboratory of Excellence (Labex GR-Ex) , Paris , France

4. Department of Paediatrics , Hôpital Paris Saclay , France

5. INSERM U1137 Infection, Antimicrobiens, Modélisation, Evolution , Paris , France

Abstract

Abstract Hydroxyurea decreases painful events among children with sickle cell disease (SCD) but could increase the risk of infections in treated patients through leucopenia. We performed a case–control study, comparing hydroxyurea treatment for SCD in cases with an invasive bacterial infection and in controls without infection. No difference was found.

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/jpids/advance-article-pdf/doi/10.1093/jpids/piae071/58703080/piae071.pdf

Reference10 articles.

1. Sickle cell disease;Ware;Lancet (London, England),2017

2. Sickle cell disease: progress towards combination drug therapy;Pace;Br J Haematol,2021

3. Predictors of splenic function preservation in children with sickle cell anemia treated with hydroxyurea;Nottage;Eur J Haematol,2014

4. Hydroxyurea therapy for sickle cell anemia;McGann;Expert Opin Drug Saf,2015

5. Hydroxyurea for children with sickle cell anemia in Sub-Saharan Africa;Tshilolo;N Engl J Med,2019