A Pediatric Infectious Diseases Perspective of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Novel Coronavirus Disease 2019 (COVID-19) in Children

Author:

Shane Andi L1,Sato Alice I2,Kao Carol1,Adler-Shohet Felice C3,Vora Surabhi B4,Auletta Jeffery J5,Nachman Sharon6,Raabe Vanessa N7ORCID,Inagaki Kengo8,Akinboyo Ibukunoluwa C9,Woods Charles10,Alsulami Abdulsalam O11,Kainth Mundeep K12,Santos Roberto Parulan13,Espinosa Claudia M14,Burns Julianne E15ORCID,Cunningham Coleen K9,Dominguez Samuel R16,Martinez Beatriz Larru17,Zhu Frank18,Crews Jonathan19,Kitano Taito20ORCID,Saiman Lisa21,Kotloff Karen22

Affiliation:

1. Division of Pediatric Infectious Disease, Department of Pediatrics, Emory University School of Medicine, Children’s Healthcare of Atlanta, Atlanta, Georgia, USA

2. Division of Pediatric Infectious Diseases, University of Nebraska Medical Center, Children’s Hospital & Medical Center, Omaha, Nebraska, USA

3. Division of Pediatric Infectious Diseases, Department of Pediatrics, Children’s Hospital of Orange County, Orange, California, USA

4. Department of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington, USA

5. Division of Pediatric Hematology/Oncology/Bone Marrow Transplant and Infectious Diseases, Department of Pediatrics, Nationwide Children’s Hospital, Columbus, Ohio, USA

6. Department of Pediatrics, Stony Brook Children’s, Stony Brook, New York, USA

7. Division of Infectious Disease, Department of Medicine and Pediatrics, New York University Langone Grossman School of Medicine, New York, New York, USA

8. Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi, USA

9. Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA

10. Department of Pediatrics, University of Tennessee College of Medicine Chattanooga, Chattanooga, Tennessee, USA

11. Division of Pediatric Infectious Disease, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA

12. Division of Pediatric Infectious Diseases, Department of Pediatrics, Cohen Children’s Medical Center, Northwell Health, New Hyde Park, New York, USA

13. Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Mississippi Medical Center, University Hospital, Jackson, Mississippi, USA

14. Division of Pediatric Infectious Disease, University of South Florida, Morsani College of Medicine, Tampa, Florida, USA

15. Division of Hospital Medicine, Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA

16. Section of Infectious Diseases, Department of Pediatrics, University of Colorado and Children’s Hospital Colorado, Aurora, Colorado, USA

17. Division of Paediatric Infectious Diseases & Immunology, Alder Hey Children’s Hospital, Liverpool, United Kingdom

18. Division of Pediatric Infectious Diseases, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA

19. Division of Pediatric Infectious Diseases, Baylor College of Medicine, Children’s Hospital of San Antonio, San Antonio, Texas, USA

20. Division of Infectious Diseases, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

21. Division of Pediatric Infectious Diseases, Department of Pediatrics, Columbia University Medical Center, New York–Presbyterian Morgan Stanley Children’s Hospital, New York, New York, USA

22. Division of Pediatric Infectious Diseases and Tropical Medicine, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA

Abstract

AbstractUnderstanding the role that children play in the clinical burden and propagation of severe acute respiratory syndrome coronavirus 2, responsible for coronavirus disease 2019 (COVID-19) infections, is emerging. While the severe manifestations and acute clinical burden of COVID-19 have largely spared children compared with adults, understanding the epidemiology, clinical presentation, diagnostics, management, and prevention opportunities and the social and behavioral impacts on child health is vital. Foremost is clarifying the contribution of asymptomatic and mild infections to transmission within the household and community and the clinical and epidemiologic significance of uncommon severe post-infectious complications. Here, we summarize the current knowledge, identify resources, and outline research opportunities. Pediatric infectious diseases clinicians have a unique opportunity to advocate for the inclusion of children in epidemiological, clinical, treatment, and prevention studies to optimize their care as well as to represent children in the development of guidance and policy during pandemic response.

Funder

Gilead Sciences

National Institutes of Health

Bill and Melinda Gates Foundation

NIH Vaccine and Treatment Evaluation Units

National Emerging Special Pathogens Training and Education Center

National Institute of Allergy and Infectious Diseases

Pfizer

Centers for Disease Control and Prevention

Merck, Inc

Cystic Fibrosis Foundation

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology and Child Health

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