Monitoring Ceftazidime-Avibactam and Aztreonam Concentrations in the Treatment of a Bloodstream Infection Caused by a Multidrug-Resistant Enterobacter sp. Carrying Both Klebsiella pneumoniae Carbapenemase–4 and New Delhi Metallo-β-Lactamase

Monitoring Ceftazidime-Avibactam and Aztreonam Concentrations in the Treatment of a Bloodstream Infection Caused by a Multidrug-Resistant Enterobacter sp. Carrying Both Klebsiella pneumoniae Carbapenemase–4 and New Delhi Metallo-β-Lactamase–1

Published:2019-12-05 Issue:4 Volume:71 Page:1095-1098
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Yasmin Mohamad¹²³⁴^ORCID,Fouts Derrick E⁵,Jacobs Michael R⁶,Haydar Hanan⁷,Marshall Steven H³,White Richard⁵,D’Souza Roshan⁵,Lodise Thomas P⁸,Rhoads Daniel D⁶,Hujer Andrea M²³,Rojas Laura J²³,Hoyen Claudia⁷,Perez Federico²³⁴,Edwards Amy²⁷,Bonomo Robert A²³⁴⁹¹⁰

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA

2. Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA

3. Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA

4. Geriatric Research, Education and Clinical Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA

5. J. Craig Venter Institute, Rockville, Maryland, USA

6. Division of Clinical Microbiology, Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA

7. Division of Pediatric Infectious Diseases, Rainbow Babies and Children’s Hospital, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA

8. Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, New York, USA

9. Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA

10. Department of Molecular Biology & Microbiology, Case Western Reserve University, Cleveland, Ohio, USA

Abstract

Abstract In an infection with an Enterobacter sp. isolate producing Klebsiella pneumoniae Carbapenemase–4 and New Delhi Metallo-β-Lactamase–1 in the United States, recognition of the molecular basis of carbapenem resistance allowed for successful treatment by combining ceftazidime-avibactam and aztreonam. Antimicrobial synergy testing and therapeutic drug monitoring assessed treatment adequacy.

Funder

National Institute of Allergy and Infectious Diseases

National Institutes of Health

Cleveland Department of Veterans Affairs

Geriatric Research Education and Clinical Center

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciz1155/32293711/ciz1155.pdf

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