Zika Virus Causing Encephalomyelitis Associated With Immunoactivation-Reference-Cited by-同舟云学术

Zika Virus Causing Encephalomyelitis Associated With Immunoactivation

Published:2016 Issue:4 Volume:3 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Galliez Rafael Mello¹²,Spitz Mariana³⁴,Rafful Patricia Piazza⁵⁶,Cagy Marcelo³⁴,Escosteguy Claudia⁷,Germano Caroline Spósito Brito³⁴,Sasse Elisa³⁴,Gonçalves Alessandro Luis⁸,Silveira Paola Paz⁸,Pezzuto Paula⁸,Ornelas Alice Maria de Magalhães⁸,Tanuri Amilcar⁸,Aguiar Renato Santana⁸,Moll Fernanda Tovar⁵⁹

Affiliation:

1. Instituto Estadual de Infectologia São Sebastião, Rio de Janeiro, Brazil

2. Programa de Pós-Graduação em Clínica Médica da Faculdade de Medicina da Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

3. University of the State of Rio de Janeiro, Brazil

4. Neurology Service and

5. D’Or Institute for Research and Education, Rio de Janeiro, Brazil

6. Radiology Department, and

7. Epidemiology Service, Hospital Federal dos Servidores do Estado, Rio de Janeiro, Brazil;

8. Genetics Department, Biology Institute, and

9. Institute of Biomedical Sciences, and National Center for Structural Biology and Bioimaging, Federal University of Rio de Janeiro, Brazil

Abstract

Abstract Brazil has experienced a Zika virus (ZIKV) outbreak with increased incidence of congenital malformations and neurological manifestations. We describe a case of a 26-year-old Brazilian Caucasian man infected with ZIKV and diagnosed with encephalomyelitis. Brain and spinal cord images showed hyperintense lesions on T2 and fluid-attenuated inversion recovery (FLAIR), and levels of proinflammatory cytokines in the cerebrospinal fluid showed a remarkable increase of interleukin (IL)-6 and IL-8. The observed pattern suggests immune activation during the acute phase, along with the neurological impairment, with normalization in the recovery phase. This is the first longitudinal report of ZIKV infection causing encephalomyelitis with documented immune activation.

Funder

Brazilian Council for Development of Science and Technology

CAPES Foundation

Brazilian Ministry of Education

Rio de Janeiro Foundation

D’Or Institute for Research and Education

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

http://academic.oup.com/ofid/article-pdf/3/4/ofw203/33602311/ofw203.pdf