Prenylated acetophenones from the roots of <i>Calendula officinalis</i> and their anti-inflammatory activity-Reference-Cited by-同舟云学术

Prenylated acetophenones from the roots of Calendula officinalis and their anti-inflammatory activity

Published:2023-04-06 Issue:7 Volume:87 Page:683-687
ISSN:1347-6947
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Kadowaki Wataru¹,Miyata Ryo¹,Mizuno Sayaka¹,Fujinami Misa²,Sato Yoshizumi²,Kumazawa Shigenori¹^ORCID

Affiliation:

1. Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka , Shizuoka , Japan

2. Kisho Corporation , Tokyo , Japan

Abstract

ABSTRACT Calendula officinalis is a medicinal plant in the Asteraceae family, and it has a broad range of biological activities. In this study, we focused on the roots of C. officinalis, which have remarkable anti-inflammatory properties. By using a bioassay-guided fractionation approach, prenylated acetophenones 1 and 2—of which 1 was previously unknown—were isolated, and their structures were determined by spectroscopic analysis. Both compounds decreased lipopolysaccharide-stimulated NO production in J774.1 cells. This study could lead to the use of the Calendula roots as a natural source of inflammatory mediators.

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

https://academic.oup.com/bbb/advance-article-pdf/doi/10.1093/bbb/zbad042/50149578/zbad042.pdf

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