A coding variant in CR1 interacts with APOE-ɛ4 to influence cognitive decline

Author:

Keenan Brendan T.12,Shulman Joshua M.123,Chibnik Lori B.123,Raj Towfique123,Tran Dong12,Sabuncu Mert R.45,Allen April N.6,Corneveaux Jason J.6,Hardy John A.78,Huentelman Matthew J.6,Lemere Cynthia A.39,Myers Amanda J.1011,Nicholson-Weller Anne312,Reiman Eric M.613,Evans Denis A.141516,Bennett David A.16,De Jager Philip L.123,

Affiliation:

1. Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, 77 Avenue Louis Pasteur, NRB168, Boston, MA 02115, USA,

2. Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA,

3. Harvard Medical School, Boston, MA 02115, USA,

4. Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 Thirteenth Street, Suite 2301, Charlestown, MA 02129, USA,

5. Computer Science and Artificial Intelligence Laboratory (CSAIL) and Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA,

6. Neurogenomics Division, Translational Genomics Research Institute and Arizona Alzheimer's Consortium, 445 North Fifth Street, Phoenix, AZ 85004, USA,

7. Laboratory of Neurogenetics, National Institute on Aging, Porter Neuroscience Research Center, Building 35, Room 1A1000, Bethesda, MD 20892, USA,

8. Reta Lila Weston Laboratories, Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London, UK,

9. Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, 7th Floor, Boston, MA 02115, USA,

10. Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL 33136, USA,

11. Johnnie B. Byrd Sr. Alzheimer's Center and Research Institute, 4001 East Fletcher Avenue, Tampa, FL 33136, USA,

12. Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02115, USA,

13. Banner Alzheimer's Institute and Department of Psychiatry, University of Arizona, 901 East Willetta Street, Phoenix, AZ 85006, USA and

14. Department of Internal Medicine,

15. Department of Neurological Science and

16. Rush Alzheimer's Disease Center, Rush University Medical Center, 600 South Paulina Street, Chicago, IL 60612, USA

Publisher

Oxford University Press (OUP)

Subject

Genetics (clinical),Genetics,Molecular Biology,General Medicine

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