Beyond the symptom: the biology of fatigue

Author:

Raizen David M1ORCID,Mullington Janet2ORCID,Anaclet Christelle3,Clarke Gerard4,Critchley Hugo5,Dantzer Robert6ORCID,Davis Ronald7,Drew Kelly L8,Fessel Josh9,Fuller Patrick M3,Gibson Erin M10,Harrington Mary11,Ian Lipkin W12ORCID,Klerman Elizabeth B1314ORCID,Klimas Nancy15,Komaroff Anthony L14,Koroshetz Walter16,Krupp Lauren17,Kuppuswamy Anna18,Lasselin Julie19ORCID,Lewis Laura D20,Magistretti Pierre J21,Matos Heidi Y16ORCID,Miaskowski Christine22,Miller Andrew H23,Nath Avindra16ORCID,Nedergaard Maiken24,Opp Mark R25,Ritchie Marylyn D26,Rogulja Dragana27,Rolls Asya28,Salamone John D29,Saper Clifford2ORCID,Whittemore Vicky16ORCID,Wylie Glenn30,Younger Jarred31,Zee Phyllis C32,Craig Heller H33

Affiliation:

1. Department of Neurology, University of Pennsylvania , Philadelphia, PA , USA

2. Department of Neurology, Harvard Medical School , Boston, MA , USA

3. Department of Neurological Surgery, University of California, Davis School of Medicine , Sacramento, CA , USA

4. Department of Psychiatry and Neurobehavioural Science, and APC Microbiome Ireland, University College Cork , Cork , Ireland

5. Brighton and Sussex Medical School Department of Neuroscience, University of Sussex , Brighton , UK

6. Department of Symptom Research, Division of Internal Medicine, University of Texas MD Anderson Cancer Center , Houston, TX , USA

7. Department of Biochemistry and Genetics, Stanford University , Palo Alto, CA , USA

8. Department of Chemistry and Biochemistry, Institute of Arctic Biology, Center for Transformative Research in Metabolism, University of Alaska Fairbanks , Fairbanks, AK , USA

9. Division of Clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health , Bethesda, MD , USA

10. Department of Psychiatry and Behavioral Sciences, Stanford University , Palo Alto, CA , USA

11. Department of Psychology, Neuroscience Program, Smith College , Northampton, MA , USA

12. Center for Infection and Immunity, and Departments of Neurology and Pathology, Columbia University , New York City, NY , USA

13. Division of Sleep Medicine, Department of Neurology, Massachusetts General Hospital, Harvard Medical School , Boston, MA , USA

14. Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School , Boston, MA , USA

15. Department of Clinical Immunology, College of Osteopathic Medicine, Nova Southeastern University , Ft. Lauderdale , FL , USA

16. National Institute of Neurological Disorders and Stroke, National Institutes of Health , Bethesda, MD , USA

17. Department of Neurology, NYU Grossman School of Medicine, NYC , NY , USA

18. University College London, Queen Square Institute of Neurology , London, England

19. Department of Psychology, Stockholm University , Stockholm , Sweden

20. Center for Systems Neuroscience, Department of Biomedical Engineering, Boston University , Boston, MA , USA

21. Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology , Thuwal , Kingdom of Saudi Arabia

22. Department of Physiological Nursing, School of Nursing, University of California , San Francisco, CA , USA

23. Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine , Atlanta, GA , USA

24. Departments of Neurology and Neurosurgery, University of Rochester Medical Center , Rochester, NY , USA

25. Department of Integrative Physiology, University of Colorado Boulder , Boulder, CO , USA

26. Department of Genetics, Institute for Biomedical Informatics, Penn Center for Precision Medicine, University of Pennsylvania , Philadelphia, PA , USA

27. Department of Neurobiology, Harvard University , Boston, MA , USA

28. Rappaport Institute for Medical Research, Technion, Israel Institute of Technology , Haifa , Israel

29. Department of Psychological Sciences, University of Connecticut , Storrs, CT , USA

30. Rocco Ortenzio Neuroimaging Center at Kessler Foundation , East Hanover, NJ , USA

31. Department of Psychology, University of Alabama, Birmingham , Birmingham, AL , USA

32. Center for Circadian and Sleep Medicine, Department of Neurology, Northwestern University Feinberg School of Medicine , Chicago, IL , USA

33. Department of Biology, Stanford University and Sleep Research Society , Stanford, CA , USA

Abstract

Abstract A workshop titled “Beyond the Symptom: The Biology of Fatigue” was held virtually September 27–28, 2021. It was jointly organized by the Sleep Research Society and the Neurobiology of Fatigue Working Group of the NIH Blueprint Neuroscience Research Program. For access to the presentations and video recordings, see: https://neuroscienceblueprint.nih.gov/about/event/beyond-symptom-biology-fatigue. The goals of this workshop were to bring together clinicians and scientists who use a variety of research approaches to understand fatigue in multiple conditions and to identify key gaps in our understanding of the biology of fatigue. This workshop summary distills key issues discussed in this workshop and provides a list of promising directions for future research on this topic. We do not attempt to provide a comprehensive review of the state of our understanding of fatigue, nor to provide a comprehensive reprise of the many excellent presentations. Rather, our goal is to highlight key advances and to focus on questions and future approaches to answering them.

Funder

National Institute of Neurological Disease and Stroke

National Institutes of Health

U.S. Department of Defense

National Heart, Lung, and Blood Institute

BrightFocus Foundation

National Cancer Institute

National Institute of Allergy and Infectious Diseases

National Institute of General Medical Sciences

Publisher

Oxford University Press (OUP)

Subject

Physiology (medical),Neurology (clinical)

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