Odor- or chemical-guided behavior is expressed in all species. Such behavioral responses to odors begin with transduction at olfactory receptors and, after initial processing in early stages of the olfactory system (e.g., vertebrate olfactory bulb, invertebrate antennal lobe), the information is rapidly (within one to two synapses) distributed to diverse brain regions controlling hedonics, metabolic balance, mating, and spatial navigation, among many other basic functions. Odors can not only drive or guide specific behavioral responses but can also modulate behavioral choices and affective state, in many cases in humans without conscious awareness. Many of the specific neural circuits underlying odor-guided behaviors have been partially described, though much remains unknown. Neural processes underlying odor-guided reward and aversion, kin recognition, feeding, orientation, and navigation across diverse species have been discussed, as well as odor modulation of human behavior and emotion.